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A nationwide UK study of surgery for Slipped Capital Femoral Epiphysis and Perthes’ Disease

About

Find out more information about the aims and methodology of the BOSS Study 

Team

Meet the team behind the BOSS Study

For patients

Learn what the BOSS Study means for your child, and how you can help us learn more about Perthes & slipped epiphysis

For doctors

Register your hospital for participation in the study and find out what we need from you.

About the BOSS Study

Our accrual to date

The British Orthopaedic Surgery Surveillance (BOSS) Study is a nationwide reporting mechanism to determine the epidemiology and outcomes in rare orthopaedic diseases. BOSS is based on other successful reporting systems in obstetrics (UKOSS) and Paediatric Surgery (BAPS-CASS.)

Why study rare diseases?

Aims of BOSS

BOSS has been developed with a nationwide collaborative of children’s orthopaedic surgeons, and is currently focusing on Slipped Capital Femoral Epiphysis (SCFE) and Perthes’ Disease.

Methodology

BOSS is based on the methodology of the British Paediatric Surveillance Unit (BPSU), which has developed an effective mechanism for surveillance of uncommon disorders in paediatrics.

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Descriptive, case-control and cohort studies are conducted through a prospective, monthly case-collection scheme. Each month, up to four nominated individuals (e.g. the orthopaedic audit lead, paediatric orthopaedic lead, nurse specialist (i.e. children’s/ hip fracture nurse) and an orthopaedic trainee) are asked to notify cases of the diseases under investigation. At the end of each month details of cases reported will be sent to the nominated lead, who will be asked to verify the completeness of the data – using a simple electronic ‘tick box’. If no cases are reported it is important a nil return is confirmed.

An electronic case report form is used to capture the details of each case. The data collection form seeks confirmation of the appropriate case definition and additional information on risk factors, management and outcomes according to the protocol relating to each condition. BOSS largely collects anonymised information only. Some centres also collect identifiable information and PROM data – these centres are ‘open’ on the NIHR portfolio. The BOSS methodology is undergoing ethics committee review.

To maximise case identification patients, parents or any doctors can identify a case to be reported, and the BOSS team will follow-up with the lead clinician within the relevant centre.  Monthly sweeps will also be undertaken of hospital episode statistics to identify new cases of diseases recorded within national statistics, and the lead clinician contacted where cases have not been recorded within the BOSS study.

The BOSS Team

Contact the BOSS Team: boss@liv.ac.uk
Mr Alwyn Abraham - Leicester Children’s Hospital
Mr Sattar Alshryda - Manchester Children’s Hospital
Mr Ed Bache - Birmingham Children’s Hospital
Mr Simon Barker - Royal Aberdeen Children’s Hospital
Mr Colin Bruce - Alder Hey Children's Hospital (Liverpool)
Ms Rachel Buckingham - Nuffield Orthopaedic Centre (Oxford)
Ms Clare Carpenter - University Hospital of Wales (Cardiff)
Mrs Belen Carsi - University Hospital of North Midlands (Stoke)
Mr Steve Cooke - University Hospitals Coventry and Warwickshire
Mr Mark Cornell - East Kent University Hospital (Margate)
Mrs Karen Daly - St Georges Hospital (London)
Mr Nev Davies - Royal Berkshire Hospital (Reading)
Ms Deborah Eastwood - Great Ormond Street (London)
Mr Rob Freeman - Robert Jones and Agnes Hunt Hospital (Shrewsbury)
Mr Antoine de Gheldhere - The Great North Children’s Hospital (Newcastle)
Mr Aresh Hashemi-Nejad - Royal National Orthopaedic Hospital (London), President BSCOS
Mr Colin Holton - Leeds Children’s Hospital
Mr Ben Holroyd - Plymouth Hospitals
Mr Richard Hopcroft - James Cooke University Hospital (Middlesbrough)
Mr James Hunter - Nottingham University Hospital
Mr Marcos Katchburian - Maidstone & Tunbridge Wells Hospital
Mr Sanjeev Madan - Sheffield Children’s Hospital
Mr Fergal Monsell (deputy CI) - Bristol Royal Hospital for Children
Mr Alastair Murray - Royal Hospital for Sick Children (Edinburgh)
Mr Fabian Norman-Taylor - Evilina London Children’s Hospital
Mr Robin Paton - Royal Blackburn Hospital
Mr Giles Pattison - University Hospitals Coventry and Warwickshire
Mr Daniel Perry - Alder Hey Children's Hospital, Liverpool.
Mr Manoj Ramachandran (deputy CI) - Barts and the London
Mr David Rowland - The Royal Hospital for Children (Glasgow)
Mr Anish Sanghrajka - Norfolk and Norwich University Hospital
Ms Kuldeep Stohr - Cambridge University Hospital
Mr Phil Thomas - University Hospital of Wales (Cardiff)
Mr Mike Uglow - Southampton General Hospital
Mr Daniel C Perry
Chief Investigator - contact him here.
MB ChB (Hons), FRCS (Eng), PhD. National Institute for Health Research (NIHR) Clinician Scientist, Senior Lecturer in Orthopaedic Surgery and Honorary Consultant Alder Hey Children's Hospital, Liverpool.
Prof Marian Knight
Collaborator & Methodologist
MA MBChB MPH DPhil FFPH FRCP Edin. National Institute for Health Research (NIHR) Research Professor in Public Health, National Perinatal Epidemiology Unit, Oxford University
Prof Matt Costa
Collaborator & Methodologist 
PhD FRCS (Tr & Orth). Professor of Orthopaedic Surgery, University of Oxford, and Honorary Consultant Trauma Surgeon, John Radcliffe Hospital, Oxford.
Prof Paula Williamson
Collaborator & Methodologist
BSc PhD. Director MCRN CTU and MRC North West Hub for Trials Methodology Research (NWHTMR) Trials Methodologist & Statistician, University of Liverpool.
Prof Michael Beresford
Collaborator & Methodologist
MBChB MRCP(UK) MCRPCH PhD. Brough Chair, Professor of Child Health, University of Liverpool.  NIHR Clinical Research Network: Theme Lead for Children, Reproductive & Childbirth, Musculoskeletal, Ophthalmology and Haematology. Honorary Consultant Paediatric Rheumatologist.  Chair, NIHR CRN: Children/Arthritis Research UK Paediatric Rheumatology CSG Director, NIHR Alder Hey Clinical Research Facility. Director, UK Experimental Arthritis Treatment Centre for Children
Jenny Preston
Patient-public involvement coordinator
Patient and Public Involvement Priority Lead at NIHR Clinical Research Network - ‎University of Liverpool